Complex cytogenetic research of cryptic chromosomal aberrations in patients with multiple myeloma
نویسندگان
چکیده
منابع مشابه
Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore.
BACKGROUND Much is known about the cytogenetic lesions that characterize multiple myeloma (MM) patients from the USA, Europe, and East Asia. However, little has been published about the disease among Southeast Asians. The aim of this study was to determine the chromosomal abnormalities of MM patients in our Singapore population. METHODS Forty-five newly-diagnosed, morphologically confirmed pa...
متن کاملDetection of recurrent cytogenetic aberrations in multiple myeloma: a comparison between MLPA and iFISH.
Multiple myeloma (MM) is a genetically heterogeneous disease with diverse clinical characteristics and outcomes. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for the detection of cytogenetic aberrations in MM patients. In the present study, MLPA analysis was applied to analyze cytogenetics of CD138 tumor cells of 59 MM samples, ...
متن کاملRole of Suppressed Immunoglobulins in Outcome of Patients With Multiple Myeloma
Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
متن کاملRole of Suppressed Immunoglobulins in Outcome of Patients With Multiple Myeloma
Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
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ژورنال
عنوان ژورنال: Russian Journal of Biotherapy
سال: 2019
ISSN: 1726-9784
DOI: 10.17650/1726-9784-2019-18-1-50-59